President Trump told media Thursday afternoon that "this was another successful mission" and he gave the military total authorization.
The GBU-43B massive ordnance air blast (MOAB), which contains 11 tonnes of explosives, was used for the first time to destroy IS caves and ammunition caches. Last week, Army Staff Sgt. Mark R De Alencar, 37, was killed in an operation by U.S. Special Forces in Achin, which is close to the Pakistani border.
The deaths have not been independently verified, but ministry spokesman Dawlat Waziri said no civilians were harmed in the massive blast that targeted a network of caves and tunnels.
The US dropping its heaviest bomb+ ever on Afghanistan is "not (about) the war on terror", it's about using the mountainous country "as (a) testing ground for new and risky weapons", said former President Hamid Karzai.
More than 1,900 IS militants, several Afghan security forces and two US soldiers have been killed in Achin and neighboring district since 2015, according to Afghan military officials.
The impact of the "mother of all bombs" dropped by USA forces in Afghanistan would have been like an quake and sends a message about Donald Trump's presidency, experts have said.
"I want 100 times more bombings on this group", he told The Associated Press.More news: Destruction in fight to take west Mosul worse than east
"U.S. forces took every precaution to avoid civilian casualties with this strike".
The US said it believed the area was so remote that no civilians were in the area.
On Twitter, Afghanistan President Ashraf Ghani approved of the strike, saying it was "designed to support the efforts of the Afghan National Security Forces (ANSF) and USA forces. conducting clearance operations in the region". "Bombing was carried out in coordination with Afghanistan", the Afghan government said.
Testifying before the Senate Armed Services Committee in February, General John Nicholson warned of a stalemate in the country. The munition was developed during the Iraq war and is an air blast-type warhead that explodes before hitting the ground in order to project a massive blast to all sides.
The Taliban on Friday also issued a statement condemning the strike.
"The United States takes the fight against ISIS very seriously and, in order to defeat the group, we must deny them operational space, which we did", Spicer said.
Meanwhile Trump has said he is keeping "all options" on the table to stop North Korea's nuclear programme, as speculation mounts that Pyongyang may soon hold another nuclear test.